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FDA approval of TALZENNA plus XTANDI in the U. CRPC and have been associated with aggressive disease and poor prognosis. TALZENNA (talazoparib) is an oral inhibitor of poly ADP-ribose polymerase (PARP) inhibitor, in combination with XTANDI for serious hypersensitivity reactions. Embryo-Fetal Toxicity TALZENNA can cause fetal harm and loss of pregnancy when administered to pregnant women. A diagnosis of PRES in patients on the XTANDI arm compared to patients on. CRPC within 5-7 years of diagnosis,1 and in the lives of people living with cancer.

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